Did you know that you can upgrade your ZEISS LSM 710 and LSM 780 with Airyscan?
Upgrade your 3- or 34-channel ZEISS LSM 710 and LSM 780 with Airyscan and benefit from increased signal-to-noise, resolution and speed for your confocal imaging. Airyscan is an additional detector for your ZEISS LSM 710 or LSM 780 system that does not require any special sample type, preparation or staining. The upgrade can be done in your lab or facility, minimizing downtime of your system.
With Airyscan, the revolutionary detection concept from ZEISS, you can use multicolor samples with any label and get image quality like you’ve never seen before. You are always able to select the optimal acquisition strategy for your sample: Simply decide whether you want to gain 1.7x higher resolution in all three dimensions – resulting in a 5x smaller confocal volume. Or push the sensitivity beyond the limits of all conventional confocals. Or use the increase in signal-to-noise ratio to speed up your image acquisition. The choice is yours.
The R&D 100 Special Recognition Award is only the latest in a series of prestigious awards for the ZEISS LSM 8 family of confocal microscopes with the ZEISS-exclusive Airyscan detector. So far, ZEISS received the people’s choice awards Select Science Scientists’ Choice and two consecutive #MyNeuroVote honours at Neuroscience 2014 and 2015 for ZEISS LSM 880 with Airyscan. Most recently, ZEISS has been awarded the Innovation Prize of the State of Thuringia for the development of the Airyscan detector.
- Increase the resolution of your imaging: with Airyscan you resolve 140 nm laterally and 400 nm axially, at 488 nm.
- Unlike other superresolution techniques, Airyscan uses scanning and optical sectioning capabilities of a confocal – perfect for thicker samples such as tissue sections or whole animal mounts that need a high penetration depth.
- Increase the signal-to-noise ratio (SNR) of your images: with Airyscan you can achieve a 4x increase in SNR over conventional confocal images.
- Perform live cell imaging with low excitation power.
- In the optional Virtual Pinhole Mode, you can decide even after the acquisition, which pinhole size best suits your application.
The Airyscan detector behaves as another detector option on your ZEISS LSM 710 or LSM 780 system. There is no restriction on sample type that can be imaged or any special sample preparation to utilize Airyscan. Airyscan takes full advantage of the excellent scanning capabilities of your ZEISS confocal to enable practical live cell superresolution imaging. The fast scanning capability of your LSM in combination with the increased sensitivity allows fast frame rates with low excitation powers. ZEISS protects your investment: With Airyscan and the included ZEN software upgrade you make sure that your LSM will stay top-of-the-line for the years to come.
The Technology Behind It:
Instead of throwing away light at the pinhole, a 32 channel area detector collects all the light of an Airy pattern simultaneously. Each detector element functions as a single, very small pinhole. Knowing the beampath and the spatial distribution of each Airy pattern enables very light efficient imaging. You can now use all the photons that your objective collected for improved resolution and SNR.
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