Cerebellum: the brain's locomotion control center. The cerebellum of a mouse is shown here in cross-section. The cerebellum is the brain's locomotion control center. Every time you shoot a basketball, tie your shoe or chop an onion, your cerebellum fires into action. Found at the base of your brain, the cerebellum is a single layer of tissue with deep folds like an accordion. People with damage to this region of the brain often have difficulty with balance, coordination and fine motor skills. Image courtesy of Thomas Deerinck, National Center for Microscopy and Imaging Research, University of California, San Diego. Part of the exhibit Life:Magnified by ASCB and NIGMS.ified by ASCB and NIGMS.